The Amazing Spider-Man Walkthrough Part 16 – Smythe Strikes Back, Part 2
Head over to the divide to the formerly protected area. A quick scene runs where the Scorpion attacks you. Unfortunately Spider-Man's little brawl with him draws the nearby Heavy Oscorp Security who unload a few rounds on the Scorpion which cause him to feel. This does not make it any easier for Spider-Man as he is left standing there in front of 2 of them. Quick Web-retreat to the ceiling to break their line of sight. It is easy enough to get one with a Stealth Take-down but the other requires more of a direct approach. Move into brawling but the moment you see the Spider Sense go Red, use Web Retreat as he drops a Gas grenade. Just wait for the cloud to break up then swoop in for another attack. Repeat as necessary to take down the Heavy.
Once the pair of Heavies are down, look to the right. There you will see an open door. Be sure to look at the fallen trash can to the right of it to find one of the collectible magazines. After that, head right through the door, carefully. At the far end of the room you will spot a turret with numerous lasers jetting out from it. Get to the ceiling or off to the side. Now, line up a Web-Strike to destroy the turret and clear part of your way forward. Be sure to check the center left and right. On the right is a magazine and on the left is a Tech Upgrade.
With the turret destroyed head on forward through the now unguarded door. Go down the first hall on the left and follow that forward. When you reach the room just before the decontamination chamber, look to the right to find another Tech Upgrade. Collect it and move on forward.
Head over to the panel and collect the Oscorp Security Manual on it then interact with it. This will shut down some of the laser grid. Just carefully Web-Rush through the area. This will get you to the fan that controls ventilation. Use your web-shooters again to slow it down so you can safely cross through. Repeat this on the fan to the right of the first one. Head down the corridor beyond it and use the console in front of you. Once again, use your Web-Rush to quickly cross through the area while the Security is lessened. Avoid taking out any of the turrets if you can (though it is quick and fun to do so).
In this decontamination chamber, head into the ventilation shaft that is above the far door. At the end of the shaft just head on forward and you will arrive where the Quarantine lab is with Gwen and the other scientists. Smythe takes the antidote but things go wrong, very wrong. He loses use of his legs and flops to the ground, blaming Spider-Man and Dr. Connors for everything. New robots will attack and they attempt to latch onto Spider-Man and self-destruct. Just head for the ceiling. Be aware on the ground, near the exit, is a Tech Upgrade.
In the next room you have a good 7 Security Members to defeat. Dash past the 4 soldiers on the floor and look to the left. You will spot a generator and a guard with a gun. Take out the fellow with the gun then destroy the generator. Just plow through the few on the floor after that. After that, head into the room with the Acid Slime to move forward.