What can you do if 2142 crashes everytime its in titan mode usin vista

Because the statement is unclear, there may be multiple reasons for this happening.

I'm sure it's not your computer operating system, but you should try by making sure your computer is working properly with the game. (check system requirements)

Next you should make sure you aren't running any programs or downloads while you play the game. This can cause it to lag badly.

Maybe you should free memory space. (seems to work sometimes)

Get faster internet connection. Very important to get something like Cable, Dsl, or faster internet, because it is one of the requirements.

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Now, if you are sure that your computer is very good and has past all of the above suggestions, you should contact EA because they are more expert at something like this.