Where can you get rune essences on RuneScape

The quest "Rune Mysteries" is a prerequisite to mine rune essence, and to make the actual runes.
There is a rune essence mine. Go to Aubury (south of the eastern Varrock bank); he will teleport you if you did the quest.
You can of course buy rune essence from the Grand Exchange - rune essence that was obtained and sold by other players.
You also get small amounts of rune essence as drops from certain monsters.