The worst ending is achieved when you die during the after credits sequence, whether you took the panacea or not.
The Wind Waker Walkthrough – Outset Island – 
The Wind Waker Walkthrough – Dragon Roost Cavern – 
Nintendo Shows Nothing New on the Wii U at CES
Call of Duty: Ghosts – Rorke Files Guide
Assassin’s Creed IV: Black Flag – Templar Hunt / Assassination Mission Guide