Fallout 4 is locked to 60 frames-per-second on the PC, 30 on consoles. Thankfully, for gamers with powerful rigs who want to experience the most out of the game, it's possible to unlock the game to run at more than 60FPS without experiencing screen tear. This only works if you're on an Nvidia card.
1) To do so, you'll first need to download the latest (358.91) Game Ready drivers for your Nvidia card.
2) Ensure that the Fallout4Prefs.ini file in your Documents/my games/Fallout4 folder is NOT set to read-only.
3) Start the Fallout 4 launcher and enter the Options. Set Motion Blur to "off", God Rays to "low", and max out everything else—provided you had the game already running on Ultra. Close the launcher.
4) Go back to the Fallout4Prefs.ini file and change the part where it says iPresentlnterval=1 to iPresentlnterval=0. Save the file, close it, and make it read-only by right-clicking the file and examining the properties.
5) Next, open the Nvidia Control Panel. Go to Manage 3D Settings. Go to the Program Settings tab, and find Fallout 4.exe. Set the vertical sync to use the application setting. Do the same for Fallout4launcher.exe.
From this point on, Fallout 4 will run at over 60 frames-per-second.
Unfortunately, because of the Gamebryo engine the game is running on, players who do this may experience some strangeness while playing the game. For starters, the game will speed up in some ways that make lockpicking impossible. Players will also run faster, and physics will behave oddly. The framerate will also drop to 60 or below when you enter third-person view, which feels jarring.
If you're experiencing any stuttering, check out our guide on how to fix that. For further reading, be sure to check out our guide on maximizing performance in Fallout 4. Disabling mouse acceleration will also help your experience.