Synths are faced almost entirely like humans, the only difference is that they are a bit more resilient and are immune to Radiation. Their skin is armor that you can break down to expose their inner workings. Synths use energy weapons pretty much exclusively. Even the melee types use batons charged with electricity, which add an extra bit of damage to their attacks and can stun you.
The trick here is to pick a spot and take out the armor for a certain area. V.A.T.S. makes this much easier, so make good use of it. Luckily, unlike many other types of robotic beings, Synths aren’t too strong against normal, ballistic fire. That makes them a relative breeze when compared to other enemy types. But, there is one type of Synth you should be wary of. Coursers are practically on steroids, and they have one job: to hunt down rogue Synths.
These guys are immensely powerful, fast, and will use invisibility when necessary. They still follow the same rules as any Synth, carrying the same weaknesses with one exception: you’ll want to use your much stronger ammunition and go for the legs above all else. Stopping these guys from moving around is of the utmost importance so that you can take them out quickly.
How have you fared in the war against Synths? Let us know in the comments below!