Play as Anubis:
Successfully complete the Ascension Rites ladder.
Play as Brock:
Successfully complete the Lauren tournament ladder.
Play as Devastation:
Reach rung 14 of the Ascension Rites ladder.
Play as Gorge:
Successfully complete the Malcolm tournament ladder.
Play as Malcolm:
Successfully complete one of each game type versus human competition.
Play as Raiden:
Complete all fifteen challenges in challenge mode to unlock Raiden from Mortal Kombat.
Play as Raiden:
Successfully complete all challenge matches.
Play as Selket:
Successfully complete the Ascension Rites ladder.
Play as Torgr:
Successfully complete the Szalor tournament ladder.
Apophis bot:
Complete rung 16 of the Ascension Rites ladder.
Calypso bot:
Complete rung 5 of the Malcolm tournament ladder.
Corrosion bot:
Complete rung 2 of the Anubis tournament ladder.
Darius bot:
Complete rung 3 of the Szalor tournament ladder.
Hyena bot:
Complete rung 7 of the Ascension Rites ladder.
Jackhammer bot:
Complete rung 5 of the Arclite tournament ladder.
Judas bot:
Complete rung 4 of the Sapphire tournament ladder.
Korig bot:
Complete rung 3 of the Raptor tournament ladder.
Kraag bot:
Complete rung 3 of the Lauren tournament ladder.
Memphis bot:
Complete rung 5 of the Brock tournament ladder.
Mirage bot:
Complete rung 5 of the Sobek tournament ladder.
Nepthys bot:
Complete rung 6 of the Gorge tournament ladder.
Syzygy bot:
Complete rung 5 of the Devastation tournament ladder.
Adrenaline Jumps mutator:
Complete rung 2 of the Lauren tournament ladder, and rung 3 of the Selket tournament ladder.
Announce Power-Ups mutator:
Complete rung 8 of the Raptor tournament ladder.
Double Adrenaline mutator:
Complete the following tournament ladder rungs: Anubis 7, Gorge 1, Lauren 1, Raiden 1, Raptor 1, Selket 1, Sobek 10, Szalor 1.
Friendly Fire Damage mutator:
Complete the Malfunction challenge or one of the following tournament ladder rungs: Arclite 6, Raptor 4, Sapphire 2.
InstaGib mutator:
Complete the Sharpshooter challenge or one of the following tournament ladder rungs: Ascension Rites 7, Gorge 9, Sapphire 3.
Looting mutator:
Complete the Malfuntion challenge or one of the following tournament ladder rungs: Arclite 2, Selket 8.
Low Grav/Low Grav All mutator:
Complete the Taking Flight challenge or one of the following tournament ladder rungs: Devastation 2, Sapphire 5.
No Lock mutator:
Complete the Graduation challenge or rung 8 of the Lauren tournament ladder.
Quad Jump mutator:
Complete the Taking Flight challenge or one of the following tournament ladder rungs: Ascension Rites 8, Arclite 8.
Radioactive mutator:
Complete the Malfunction challenge or rung 4 of the Gorge tournament ladder.
Random Pickup Respawn mutator:
Complete the Malfuntion challenge or one of the following tournament ladder rungs: Arclite4, Devastation 8, Gorge 8.
Retribution mutator:
Complete the Graduation challenge or one of the following tournament ladder rungs: Brock 9, Malcolm 5, Selket 7, or Torgr 8.
Rounds Best of 3 or 5 mutator:
Complete rung 12 of Ascension Rites or rung 8 of the Torgr tournament ladder.
Vampire mutator:
Complete the Day Of The Vampire challenge
Volatile mutator:
Complete the Malfunction challenge or one of the following tournament ladder rungs: Brock 6, , Sobek 4.
Wall Crawl mutator:
Complete rung 3 of the Raiden tournament ladder.
Weapon Master mutator:
Complete rung 3 of the Malcolm tournament ladder.