Set the game difficulty to "All-Madden". Then, go into the AI settings and set all of the human stats QB Accuracy, O-line Pass Blocking, etc. to the maximum. Next, set all the CPU stats to the lowest. Set the quarters to five minutes and choose a team with a good running back, such as Seattle or Washington. It will still be difficult to pass even with the CPU stats as low as they are. You should be able to rack up well over 500 rushing yards. You should get over 700 Madden Tokens per game.
Information in this section was contributed by cody hobbins.
Recommended defense:
Try blitzing on first and second downs but not on the third down. Your opponent may be used to rushing his throws and throw the ball right into your coverage.
Information in this section was contributed by Seth Kamens.
If you choose a 4-3 or a 3-4 defense against any team, select a play in which you blitz all your linebackers and have your defensive backs cover the receivers. This works about 90 of the time. You will average at least five sacks per game.
Choosing the correct parents:
When starting Hall Of Fame mode, certain parents will give you large boosts in key stats. If you want a receiver that is very fast, look for a hall of fame WR father with the note "He was the Randy Moss of his time". You should end up with 95 or higher speed. If you want a fast quarterback, look for a Pro Bowl or Hall of Fame QB father with the note "He was the Michael Vick of his time". You will be insanely fast and have good throwing power. Note: Do not chose a father with the note "He was his era's Tom Brady." He will be extremely slow 55 or less speed and not be able to outrun anyone.
Avoiding injuries:
When you think one of your players may be injured on offense, hurry the play up and they will get back up