Does a graphics media accelerator 4500mhd work on gta 4 with 3 GB 2ghz core 2 duo

It would -- , so it's a pretty capable integrated graphics (don't listen to those who say otherwise about it) -- but expect a lot of lag.

install the 1.0.4.0 patch so you can disable shadows and probably the reflections, and use performance tweaks such as the farclip tweak.

If your laptop is upgradeable, you may want to install a discrete graphics card. If you can't upgrade the graphics, try upgrading your RAM to a 4 GB. Having dual channel and the same set of memory modules, as well as a high memory speed (i.e. 800 MHz), help a lot in performan