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Is it possible to install a PC game onto a flash drive and be able to play it on another computer

Is it possible to install a PC game onto a flash drive and be able to play it on another computer
This will depend on the game, but in general it is not possible with larger games. Most larger games require writing data to the registry, which wouldn't be available on another computer. They will also usually default to saving games in your User settings folder, although you may be able to change this.